Combinations

Blends & stacks

Documented combinations, plus a plain-language guide to which peptides combine well and which to keep apart. Combination evidence is almost always thinner than single-agent evidence, so everything here is framed conservatively.

Stacking compatibility

What to stack, what to avoid

A quick reference built on one rule: combine peptides with different mechanisms, not two that do the same thing.

Check your own stack

Stack well togetherDifferent, complementary mechanisms

CJC-1295 + Ipamorelin
A GHRH analog paired with a selective ghrelin-receptor peptide. They raise growth hormone through two different pathways, and ipamorelin is selective enough to avoid the large cortisol and prolactin spikes seen with older GHRPs.
CJC-1295 Ipamorelin
BPC-157 + TB-500
Two repair peptides with different reported mechanisms (BPC-157 favors angiogenesis and gut lining, TB-500 favors cell migration). They are commonly paired in recovery research, though human evidence for either remains limited.
BPC-157 TB-500
Cagrilintide + Semaglutide
An amylin analog plus a GLP-1 agonist act on complementary appetite pathways. This specific pair is being developed and trialed as a single combination product (CagriSema), so the combination itself has dedicated human data.
Cagrilintide Semaglutide
Sermorelin + GHRP-2
A GHRH analog plus a growth-hormone-releasing peptide, the classic two-pathway approach to a stronger, more natural GH pulse than either alone.
Sermorelin GHRP-2

Use cautionOverlapping or additive effects

MK-677 + any GH secretagogue
MK-677 already raises growth hormone and IGF-1 strongly on its own. Adding another secretagogue compounds water retention, appetite, and insulin-resistance effects for little clear added benefit.
MK-677 Ipamorelin
Two ghrelin-receptor GHRPs together
Stacking two peptides that hit the same ghrelin receptor (for example ipamorelin with GHRP-6 or hexarelin) is largely redundant and increases hunger, cortisol, and prolactin without a clear reason.
Ipamorelin GHRP-6
Melanotan II with stimulants or blood-pressure changes
Melanotan II affects blood pressure and the cardiovascular system. Combining it with stimulants or other vasoactive compounds deserves caution and monitoring.
Melanotan II

Avoid combiningSame pathway, added risk, no benefit

Two GLP-1 based drugs together
Do not stack two incretin agonists (for example semaglutide with tirzepatide, or with liraglutide). They act on the same pathway, so side effects like nausea, vomiting, and dehydration add up while there is no evidence of extra benefit. Switch between them under medical care rather than combining.
Semaglutide Tirzepatide
Two GHRH analogs together
Two peptides that both act as GHRH analogs are redundant. One occupies the same receptor the other would, so the combination adds cost and variables, not effect.
CJC-1295 Sermorelin
Multiple sedating or sleep peptides at once
Layering several compounds that affect sleep or the central nervous system at the same time makes effects and side effects hard to attribute and can be additive. Add one variable at a time.
DSIP

Stacking basics

Stack peptides with different, complementary mechanisms that point at the same goal, not two that do the same thing.
Avoid combining two peptides that act on the same receptor or pathway. It is usually redundant and the side effects add up.
More peptides means more variables and more risk. Start with the smallest stack that could work, and add one thing at a time.
Evidence for a combination is almost always weaker than evidence for each peptide alone. Treat stack claims with extra caution.
None of this is medical advice. Any combination should involve a qualified clinician who knows your history and medications.

Documented

Blend profiles

Specific combinations with their own structured profile, evidence tier, and safety notes.

Single peptides

Limited evidence Growth hormone support

CJC-1295 + Ipamorelin

This is the most common growth-hormone peptide pairing. CJC-1295 is a GHRH analog and ipamorelin is a selective ghrelin-receptor peptide, so the two raise growth hormone through different pathways at the same time. Human evidence for the combination itself is limited.

View blend

Preliminary evidence Tissue repair

BPC-157 + TB-500

A common recovery pairing of two repair peptides with different reported mechanisms. BPC-157 is studied for tendon, gut, and wound healing, while TB-500 is studied for cell migration and blood-vessel growth. Almost all of the evidence is from animals, and the blend itself is untested in people.

View blend

Moderate evidence Weight management

Cagrilintide + Semaglutide

An amylin analog combined with a GLP-1 agonist. Unlike most peptide stacks, this exact pairing is being developed as a single combination product and has been studied in large human trials, so the combination itself, not just the parts, has real evidence.

View blend